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Browsing Investigaciones by Author "Alvarez-Chacon, Carla"

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An in silico evaluation of lorlatinib as a potential therapy for novel amino acid substitutions in the tyrosine kinase domain of the ALK protein associated with cancer

Zapata Dongo, Richard Junior; Poterico, Julio A.; Fontana, Diletta; Mologni, Luca; Alvarez-Chacon, Carla; Rojas-Armas, Juan; Calla, Jaeson (Frontiers Media S.A.CH, 2025-06-18)

The anaplastic lymphoma kinase (alk) gene on chromosome 2 encodes a receptor tyrosine kinase protein essential for key signaling pathways regulating cell proliferation and differentiation. Mutations in alk have been ...